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2 edition of synthesis and properties of 4 - substituted pyrrolidine-2, 3-diones found in the catalog.

synthesis and properties of 4 - substituted pyrrolidine-2, 3-diones

Frank Robert Mumford

synthesis and properties of 4 - substituted pyrrolidine-2, 3-diones

by Frank Robert Mumford

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Published by Leicester Polytechnic in Leicester .
Written in English


Edition Notes

Thesis (Ph.D.) - Leicester Polytechnic, Leicester 1981.

StatementFrank Robert Mumford.
ContributionsUniversity of London.
ID Numbers
Open LibraryOL17953387M

Abstract. A series of novel 6-(sec-butyl)methyl(substituted phenyl)-5,6- dihydropyrrolo[3,4-c]pyrazol(1H)ones 5a–h were synthesized using L-isoleucine methyl ester hydrochloride as the starting structures were characterized by 1 H NMR, FT-IR, EI-MS and elemental analysis. Compound 5f was further analyzed by single-crystal X-ray diffraction. Search results for pyrrolidine-2,5-dione at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare.

A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane, was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted allenoates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams containing five contiguous stereogenic centers were obtained in high Cited by: 3. 2-(Arylsulfonyl)indane-1,3-diones, earlier synthesized by Claisen condensation involving diethyl phthalate and aryl methyl sulphones, are found to be potent blood anticoagulants. In search of improved analogs of 2-(arylsulfonyl)indane-1,3-dione, we have synthesized them (7 a-f) by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates in the Cited by: 4.

Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1,3-diones: Mn(III)-Initiated Facile Oxygenation of Heterocyclic 1,3-Dicarbonyl Compounds: A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones: Fluorescence properties of 4-acyl isochroman-1,3-diones.   The 3-chloroaryl pyrrolidine-2,5-diones strongly inhibited the activity of human carbonic anhydrase I and II, with K i values in the low nanomolar range of – nmol/L against human carbonic anhydrase I and – nmol/L against human carbonic anhydrase by:


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Synthesis and properties of 4 - substituted pyrrolidine-2, 3-diones by Frank Robert Mumford Download PDF EPUB FB2

A series of 3-[(α-hydroxy-substituted) benzylidene]pyrrolidine-2,4-dione derivatives were synthesized as candidate herbicides by reacting different aroyl acetates with N-substituted glycine new compounds were identified by 1 H NMR spectroscopy and.

Synthesis of 3,4- and 2,3,4-substituted pyrrolidines An appropriate methyl-substituted amine 1e, bearing an electron-deficient olefin, was prepared from the Michael adduct 11 23 by DIBAL-H reduction of Boc-protec followed by Wittig olefination of the resulting aldehyde and N -deprotection Cited by: The aforementioned results demonstrate that the synthesis of 4-substituted 3-(o~-hydroxyethyl) 4-Substituted cis(a-hydroxyethyl)-pyrrolidineones l pyrrolidineones 6 out of dioxanone 1 is advantageous if the total transformation starts with aldol reaction followed by Michael-addition (i.e.

1~) rather than going the reversed Cited by: 6. In the search for better herbicides a series of 1-alkyl(α-hydroxy-(un)substituted benzylidene)pyrrolidine-2,4-diones were prepared and their structure-activity relationships studied. All their structures have been confirmed by 1H-NMR andelemental analysis.

The preliminary bioassay results indicated that some of them have highherbicidal activity against annual dicotyledonous and Cited by: 8. anti-seizure agents, a series of 3-phenyl-pyrrolidine-2,5-diones as well as 2-azaspiro[]nonane- and []decane-1,3-diones containing the pyridine moi-ety at the imide nitrogen atom have been described ().

Many of these compounds exhibited potent anticonvulsant properties in the maximal elec-troshock seizure (MES) and/or pentylenetetrazole.

The invention relates to the use of (3,4-di- 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these Author: C埃尔哈特, ELJ洛蒂瓦, H塞尔纳, JK麦鲍姆, N奥斯特曼, 入江统.

Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents Article Jan   Jung J, Oh S, Kim W, Park W, Kong J, Park O () Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues.

J Heterocycl Chem Cited by: 1. The study was designed to apply the Topliss approach to structure-activity correlations in this novel series of 2-substitutedazaspiro[]nonane-1,3-diones and 2,4-disubstitutedazaspiro[ A facile, diastereoselective synthesis of highly substituted pyrrolidine-2,3-diones is reported, along with the one-step conversion of these heterocycles to novel β-amino acids and further.

Synthesis and Anticonvulsant Properties of New Mannich Bases Derived from 3-Aryl-pyrrolidine-2,5-diones. Part 1. Archiv der Pharmazie(6), Cited by: The synthesis of 4-substituted 1-(4-iodophenyl)pyrrolidine-2,5-dione derivatives was achieved through an addition reaction between amines and a thiol in the presence of PMDTA as a base and a copper salt.

The derivatives containing a terminal acetylene moiety were converted to the corresponding 1,4-triazolyl by: 2. Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids.

Twenty-seven novel pyrrolidine-2,4-dione derivatives containing N-substituted phenylhydrazine moiety were synthesized. Their structures were confirmed by 1H NMR, 13C NMR and MS.

The half effective concentration (EC50) values of the title compounds against the phytopathogenic fungi Rhizoctonia cerealis were evaluated.

Compounds 6l and 6q displayed good bioactivity with Cited by: 5. imide derivatives (). Based on this facts, in our earlier studies we have described anticonvulsant properties of many 2-azaspiro[]nonane- and []decane-1,3-diones differently substituted at the imide nitrogen atom ().

The structure-activity relationship studies conducted with these groups of compounds revealed that their activity. The synthesis, physicochemical and pharmacological properties of new N-phenylamino derivatives of 2-azaspiro[]nonane-1,3-dione (8–10), 2-azaspiro[]decane-1,3-dione (11–18) and 3-cyclohexyl-pyrrolidine-2,5-dione (19, 20) derivatives were anticonvulsant properties of those compounds were examined by a maximal electroshock (MES) and a pentylenetetrazole (scPTZ) tests, Cited by: Pergamon Tetrahedron Letters 39 () TETRAHEDRON LETTERS Asymmetric Synthesis of 2,4-Disubstituted Pyrrolidines Qian Wang, N.

Andr6 Sasaki* and Pierre Potier lnstitut de Chimie des Substances Naturelles, CNRS, Gif-Sur-Yvette, France Received 30 April ; accepted 31 May Abstract: A new strategy for asymmetric synthesis of 2,4-disubstituted pyrrolidines is described Cited by: 7.

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure.

The applicability of the rearrangement reaction is by: 9. Synthesis of the (Z) and (E) isomers of 1,2-diarylmethyl-4,5-dioxopyrrolidinecarboxylic acid esters.

Structural assignment by nmr and mass spectroscopy. Journal of Heterocyclic Chemistry27 (7), Cited by: 9. A series of N-phenyl- and N-benzylazaspiro[]nonane- and []decane-1,3-diones containing a fluoro or trifluoromethyl substituents at the aryl ring was synthesized and tested for their.

Synthesis and anticonvulsant properties of new 1-(2-pyridinyl)- 3-substituted pyrrolidine-2,5-dione derivatives Article (PDF Available) in Acta poloniae pharmaceutica 65(4) July A copper(I)/ClickFerrophos complex catalyzed the asymmetric 1,3-dipolar cycloaddition of methyl N-benzylideneglycinates with electron deficient alkenes to give exo-2,4,5-trisubstituted and 2,3,4,5-substituted pyrrolidines in good yields with high diastereo- and enantioselectivities.

S.-i. Fukuzawa, H. Oki, Org. Lett.,10,   Pyrrolidine-2,5-diones derivates are an important class of heterocylic compounds with essential applications in the organic synthesis and medicinal chemistry. In the organic field, pyrrolidine-2,5-diones derivates, such as well known 1-bromopyrrolidine-2,5-dione (NBS), are the most commonly used halogenation by: 3.